abstract：:Suspicion that fructose-containing caloric sweeteners (FCCS) may play a causal role in the development of metabolic diseases has elicited intense basic and clinical research over the past 10 years. Prospective cohort studies converge to indicate that FCCS, and more specifically sugar-sweetened beverages (SSBs), consum...

journal_title：Current diabetes reports

authors： Tappy L,Lê KA

更新日期：2015-08-01 00:00:00

abstract：:Glucose effectiveness (SG) is the ability of glucose per se to stimulate its own uptake and to suppress its own production under basal/constant insulin concentrations. In an individual, glucose tolerance is a function of insulin secretion, insulin action and SG. Under conditions of declining insulin secretion and acti...

journal_title：Current diabetes reports

authors： Dube S,Errazuriz-Cruzat I,Basu A,Basu R

更新日期：2015-06-01 00:00:00

abstract：:Patients with type 1 diabetes (T1D) suffer excess mortality from cardiovascular disease (CVD) that has persisted despite substantial reductions in microvascular complications. Although T1D and type 2 diabetes (T2D) are etiologically distinct, it has generally been assumed that CVD in T1D is "the same disease" as that ...

journal_title：Current diabetes reports

authors： Lipes MA,Galderisi A

更新日期：2015-05-01 00:00:00

abstract：:The transition from intravenous (IV) to subcutaneous (SQ) insulin in the hospitalized patient with diabetes or hyperglycemia is a key step in patient care. This review article suggests a stepwise approach to the transition in order to promote safety and euglycemia. Important components of the transition include evalua...

journal_title：Current diabetes reports

authors： Kreider KE,Lien LF

更新日期：2015-05-01 00:00:00

abstract：:Lipodystrophies are a genetically heterogeneous group of disorders characterized by loss of subcutaneous adipose tissue and metabolic dysfunction, including insulin resistance, increased levels of free fatty acids, abnormal adipocytokine secretion, and ectopic fat deposition, which are also observed in patients with v...

journal_title：Current diabetes reports

authors： Ficarella R,Laviola L,Giorgino F

更新日期：2015-03-01 00:00:00

abstract：:In normal physiology, glucagon from pancreatic alpha cells plays an important role in maintaining glucose homeostasis via its regulatory effect on hepatic glucose production. Patients with type 2 diabetes suffer from fasting and postprandial hyperglucagonemia, which stimulate hepatic glucose production and, thus, cont...

journal_title：Current diabetes reports

authors： Lund A,Bagger JI,Christensen M,Knop FK,Vilsbøll T

更新日期：2014-12-01 00:00:00

abstract：:Overnutrition is a major cause of diabetes. The contrary situation of undernutrition has also been suggested to increase the risk of the disease. Especially undernutrition during prenatal life has been hypothesized to program the structure and physiology of the fetus in such a way that it is more prone to develop diab...

journal_title：Current diabetes reports

authors： de Rooij SR,Roseboom TJ,Painter RC

更新日期：2014-10-01 00:00:00

abstract：:Painful neuropathies are frequently encountered in clinical practice as an early or late complication of several systemic disorders. Among them, diabetes is one of the most important due to its epidemiology and the relevance for regulatory agencies in the assessment of efficacy of new analgesics. However, the presenta...

journal_title：Current diabetes reports

authors： Lauria G,Ziegler D,Malik R,Merkies IS,Waxman SG,Faber CG,PROPANE Study group.

更新日期：2014-10-01 00:00:00

abstract：:Goal setting is a widely used behavior change tool in diabetes education and training. Prior research found specific relatively difficult but attainable goals set within a specific timeframe improved performance in sports and at the workplace. However, the impact of goal setting in diabetes self-care has not received ...

journal_title：Current diabetes reports

authors： Miller CK,Bauman J

更新日期：2014-08-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) plays a pivotal role in the development of diabetic macular edema (DME), the leading cause of vision loss among working-aged individuals. A decade of clinical trials demonstrated that drugs that bind soluble VEGF restore the integrity of the blood-retinal barrier, resolve macu...

journal_title：Current diabetes reports

authors： Stewart MW

更新日期：2014-08-01 00:00:00

abstract：:Type 2 diabetes mellitus (T2DM) is a complex metabolic disease characterized by the loss of beta-cell secretory function and mass. The pathophysiology of beta-cell failure in T2DM involves a complex interaction between genetic susceptibilities and environmental risk factors. One environmental condition that is gaining...

journal_title：Current diabetes reports

authors： Rakshit K,Thomas AP,Matveyenko AV

更新日期：2014-04-01 00:00:00

abstract：:The patient-centered medical home (PCMH) is an innovative care model for the provision of primary care that is being rapidly adopted in the U.S. with the support of federal agencies and professional organizations. Its goal is to provide comprehensive, patient-centered care with increased access, quality, and efficienc...

journal_title：Current diabetes reports

authors： Ackroyd SA,Wexler DJ

更新日期：2014-03-01 00:00:00

abstract：:Cell therapy has enormous potential for the treatment of conditions of unmet medical need. Cell therapy may be applied to diabetes mellitus in the context of beta cell replacement or for the treatment of diabetic complications. A large number of cell types including hematopoietic stem cells, mesenchymal stem cells, um...

journal_title：Current diabetes reports

authors： Liew A,O'Brien T

更新日期：2014-03-01 00:00:00

abstract：:The occurrence and progression of nephropathy associated with early onset type 2 diabetes (T2D) is a consequence of the ongoing epidemic of childhood obesity. Minimal evidence regarding treatment effectiveness of renovascular comorbidities in youth with early onset T2D is available, due to the relatively recent emerge...

journal_title：Current diabetes reports

authors： Solis-Herrera C,Triplitt CL,Lynch JL

更新日期：2014-02-01 00:00:00

abstract：:Over the past 8 years, the genetics of complex traits have benefited from an unprecedented advancement in the identification of common variant loci for diseases such as type 2 diabetes (T2D). The ability to undertake genome-wide association studies in large population-based samples for quantitative glycaemic traits ha...

journal_title：Current diabetes reports

authors： Marullo L,El-Sayed Moustafa JS,Prokopenko I

更新日期：2014-01-01 00:00:00

abstract：:Neonatal hypoglycemia is an important consequence for the infant of the mother with diabetes. We have reviewed 24 published papers of various protocols for control of glucose in pregnant diabetic women during labor and delivery including our own published work. A relationship of maternal glucose during labor and neona...

journal_title：Current diabetes reports

authors： Ryan EA,Al-Agha R

更新日期：2014-01-01 00:00:00

abstract：:In this review article, we first present a brief overview of the vascular and neural components of diabetic retinopathy. Next, the multifocal electroretinogram (mfERG) technique, which can map neuroretinal function noninvasively, is described. Findings in diabetic retinal disease using the mfERG are reviewed. We then ...

journal_title：Current diabetes reports

authors： Bearse MA Jr,Ozawa GY

更新日期：2014-01-01 00:00:00

abstract：:The common form of hereditary hemochromatosis is an autosomal recessive disorder most prevalent in Caucasians that results in excessive iron storage. The clinical manifestations of hemochromatosis are protean. HFE genotype, which determines the degree of iron overload and duration of disease have profound effects on d...

journal_title：Current diabetes reports

authors： Creighton Mitchell T,McClain DA

更新日期：2014-01-01 00:00:00

abstract：:Type 1 diabetes (T1D) is a complex chronic disease that has many facets for successful management. The burden of this management falls largely on the individual and their family members. Self-management has a major influence on T1D health outcomes, and with successful management, children and adolescents with T1D can ...

journal_title：Current diabetes reports

authors： Naranjo D,Mulvaney S,McGrath M,Garnero T,Hood K

更新日期：2014-01-01 00:00:00

abstract：:Bariatric surgery has emerged as the most durably effective treatment of type 2 diabetes (DM). However, the mechanisms governing improvement in glucose homeostasis have yet to be fully elucidated. In this review we discuss the various types of surgical interventions and the multitude of factors that potentially mediat...

journal_title：Current diabetes reports

authors： Nguyen KT,Korner J

更新日期：2014-01-01 00:00:00

abstract：:Fasting glucose and hemoglobin A1c (HbA1c) are the standard measures for diagnosis and monitoring of diabetes. There has been recent interest in nontraditional markers of hyperglycemia, including fructosamine, glycated albumin, and 1,5-anhydroglucitol (1,5-AG), as alternatives or adjuncts to standard measures. There i...

journal_title：Current diabetes reports

authors： Parrinello CM,Selvin E

更新日期：2014-01-01 00:00:00

abstract：:The Fat mass and obesity associated (FTO) gene is a newly identified genetic factor for obesity. However, the exact molecular mechanisms responsible for the effect of FTO on obesity remain largely unknown. Recent studies from genome-wide associated studies reveal that genetic variants in the FTO gene are associated no...

journal_title：Current diabetes reports

authors： Zhao X,Yang Y,Sun BF,Zhao YL,Yang YG

更新日期：2014-01-01 00:00:00

abstract：:Continuous glucose monitoring (CGM) is an emerging technology that provides a continuous measure of interstitial glucose levels. In addition to providing a more complete pattern of glucose excursions, CGMs utilize real-time alarms for thresholds and predictions of hypo- and hyperglycemia, as well as rate of change ala...

journal_title：Current diabetes reports

authors： DeSalvo D,Buckingham B

更新日期：2013-10-01 00:00:00

abstract：:Beta cell replacement therapy has been proposed as a novel therapy for the treatment of type 1 diabetes. The proof of concept has been demonstrated with successful islet allotransplantation. Islet xenotransplantation has been proposed as an alternative, more reliable, and infinite source of beta cells. The advantages ...

journal_title：Current diabetes reports

authors： O'Connell PJ,Cowan PJ,Hawthorne WJ,Yi S,Lew AM

更新日期：2013-10-01 00:00:00

abstract：:Diabetic retinopathy (DR) is a vision-threatening complication of diabetes. Timely diagnosis and intervention are essential for treatment that reduces the risk of vision loss. A good color retinal (fundus) photograph can be used as a surrogate for face-to-face evaluation of DR. The use of computers to assist or fully ...

journal_title：Current diabetes reports

authors： Li B,Li HK

更新日期：2013-08-01 00:00:00

abstract：:Diabetes mellitus is a chronic disease with a higher risk of associated infections. HIV infection severely affects diabetic patients and acts as a significant health concern. Highly active antiretroviral therapy (HAART) has changed HIV from an acute infection to a chronic infection with associated significant metaboli...

journal_title：Current diabetes reports

authors： Kalra S,Agrawal N

更新日期：2013-06-01 00:00:00

abstract：:Cardiovascular disease (CVD) remains the leading cause of death among adults with diabetes, and CVD prevention remains a major challenge. Coronary artery calcium (CAC) score measured by electron beam tomography (EBT) or multi-slice detector computed tomography correlates closely with plaque burden and coronary angiogr...

journal_title：Current diabetes reports

authors： Snell-Bergeon JK,Budoff MJ,Hokanson JE

更新日期：2013-06-01 00:00:00

abstract：:Type 2 diabetes is a progressive disease characterized by the need for additional antidiabetic agents overtime to maintain a stable level of glycemic control. The discovery of the glucagon like peptide 1, 1 of the 2 major incretins, was pivotal to the development of novel therapies, which can be used in individuals wi...

journal_title：Current diabetes reports

authors： Eckerle Mize DL,Salehi M

更新日期：2013-06-01 00:00:00

abstract：:The incidence of both type 1 and type 2 diabetes is increasing globally, most likely explained by environmental changes, such as changing exposures to foods, viruses, and toxins, and by increasing obesity. While cardiovascular disease (CVD) mortality has been declining recently, this global epidemic of diabetes threat...

journal_title：Current diabetes reports

authors： Duca L,Sippl R,Snell-Bergeon JK

更新日期：2013-06-01 00:00:00

abstract：:Obesity is a state of metabolic dysregulation of the whole organism and a major contributing factor to the epidemic of insulin resistant diabetes. The nonpharmacologic treatment of obesity with bariatric surgery results in a dramatic and almost instantaneous reversal of insulin resistance. The present review collectiv...

journal_title：Current diabetes reports

authors： Khalaf KI,Taegtmeyer H

更新日期：2013-04-01 00:00:00

abstract：:Of the many innovations in health care delivery proposed in the context of health reform for those with chronic diseases such as diabetes, the group visit model is relatively easy to implement and is effective for improving health outcomes and patient and provider satisfaction, with a neutral to positive effect on hea...

journal_title：Current diabetes reports

authors： Eisenstat SA,Ulman K,Siegel AL,Carlson K

更新日期：2013-04-01 00:00:00

abstract：:The epidemic of childhood obesity has led to a remarkable increase in the prevalence of type 2 diabetes (T2D) among youth worldwide. The decreasing age at onset of T2D has alarming public health implications. In particular, the longer duration of the disease, as well as the faster onset and progression of T2D related ...

journal_title：Current diabetes reports

authors： Giannini C,Caprio S

更新日期：2013-02-01 00:00:00

abstract：:Hypoglycemia is a common problem in hospitalized patients, particularly the elderly, frail, and severely ill. Hypoglycemia has been implicated in the development of adverse clinical outcomes, including increased mortality. Fear of iatrogenic hypoglycemia remains an obstacle to adequate inpatient glycemic control. Howe...

journal_title：Current diabetes reports

authors： Carey M,Boucai L,Zonszein J

更新日期：2013-02-01 00:00:00

abstract：:Diagnostic criteria for diabetes in children have not been established with nearly the rigor as that employed in adults. Recently revised American Diabetes Association (ADA) criteria allowed utilization of hemoglobin A(1c) (HbA1c) ≥ 6.5 % for diagnosis of diabetes. A recent series of pediatric studies appear to show t...

journal_title：Current diabetes reports

authors： Kapadia CR

更新日期：2013-02-01 00:00:00

abstract：:Pharmacologic doses of glucocorticoids and chronic renal failure are challenging comorbidities and complications for safe and effective dosing of insulin for the management of hospitalized patients with diabetes. Glucocorticoids are used widely in hospitalized patients and will commonly provoke new-onset hyperglycemia...

journal_title：Current diabetes reports

authors： Baldwin D,Apel J

更新日期：2013-02-01 00:00:00

abstract：:The genomes of many species have now been completely sequenced including human and mouse. Great progress has been made in understanding the complex genetics that underlie diabetes and obesity in human populations. One of the current challenges is the functional identification and characterization of the genes within l...

journal_title：Current diabetes reports

authors： McMurray F,Moir L,Cox RD

更新日期：2012-12-01 00:00:00

abstract：:For patients with severe chronic pancreatitis refractory to medical interventions, total pancreatectomy can be considered to relieve the root cause of pain. The goal of a simultaneous islet autotransplant is to prevent or minimize the otherwise inevitable surgical diabetes. Islet autotransplant can successfully preser...

journal_title：Current diabetes reports

authors： Bellin MD,Balamurugan AN,Pruett TL,Sutherland DE

更新日期：2012-10-01 00:00:00

abstract：:Type 1 diabetes mellitus is a chronic disease that results from the autoimmune response against pancreatic insulin producing β cells. Apart of several insulin regimens, since the decade of 80s various immunomodulatory regimens were tested aiming at blocking some steps of the autoimmune process against β cell mass and ...

journal_title：Current diabetes reports

authors： Couri CE,de Oliveira MC,Simões BP

更新日期：2012-10-01 00:00:00

abstract：:Long-standing type 1 diabetes (T1D) is associated with an absolute loss of endogenous insulin secretion (circulating C-peptide is undetectable) and a related defect in glucose counter-regulation that is often complicated by hypoglycemia unawareness, markedly increasing the risk for severe hypoglycemia. Both the transp...

journal_title：Current diabetes reports

authors： Rickels MR

更新日期：2012-10-01 00:00:00

abstract：:Unfortunately, the only approved medical treatment for type 1 diabetes mellitus (DM) is insulin, despite the fact that tight control cannot be reached without some serious side effects such as hypoglycemia and weight gain. More and more importance is now shifted towards developing new drugs that can reach a better gly...

journal_title：Current diabetes reports

authors： Issa CM,Azar ST

更新日期：2012-10-01 00:00:00